Phosphorylation-mediated signalling in DNA damage response and cancer
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|Title of the Programme||Czech-Norwegian Research Programme|
|Title of the Project||Phosphorylation-mediated signalling in DNA damage response and cancer|
|Number of the Project||7F14061|
Institute of Molecular Genetics of the ASCR, v. v. i.
|Name of Norwegian Partner(s)||
Oslo University Hospital
|Name of Local Partner(s)||
Palacký University in Olomouc
|Objective of the Project||
The DNA damage response (DDR) network is essential for maintenance of genome integrity and provides an intrinsic barrier preventing tumorigenesis. Here we will investigate the role of two major classes of protein phosphatases PP2Cdelta and PP1 in acute and recovery phases of the DDR and address their involvement in cancer predisposition. Further, we will elucidate the role of Cdc7/Dbf4 kinase in stabilization of DNA replication forks and in cellular response to replication stress. This project will increase our knowledge of general molecular mechanisms of cell function and identify new pathogenic mechanisms contributing to cancer development and potentially also novel candidate biomarkers and pharmacological targets.
968 943 EUR
|Project Duration||Start date: 7th August 2014, End date: 30th April 2017|