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Phosphorylation-mediated signalling in DNA damage response and cancer

Department 58 – International Relations
Department 58 – International Relations


Updated 23-12-2014
  • region changed

RegionNational coverage
Title of the ProgrammeCzech-Norwegian Research Programme
Title of the ProjectPhosphorylation-mediated signalling in DNA damage response and cancer
Number of the Project7F14061
Project Promoter

Institute of Molecular Genetics of the ASCR, v. v. i.

Name of Norwegian Partner(s)

Oslo University Hospital

Name of Local Partner(s)

Palacký University in Olomouc

Objective of the Project

The DNA damage response (DDR) network is essential for maintenance of genome integrity and provides an intrinsic barrier preventing tumorigenesis. Here we will investigate the role of two major classes of protein phosphatases PP2Cdelta and PP1 in acute and recovery phases of the DDR and address their involvement in cancer predisposition. Further, we will elucidate the role of Cdc7/Dbf4 kinase in stabilization of DNA replication forks and in cellular response to replication stress. This project will increase our knowledge of general molecular mechanisms of cell function and identify new pathogenic mechanisms contributing to cancer development and potentially also novel candidate biomarkers and pharmacological targets.

Approved grant

968 943 EUR

Project DurationStart date: 7th August 2014, End date: 30th April 2017