Fast and sensitive bioanalysis using micromachined electrospray interfaces with μ-scale separations
Published
| Region | South Moravian Region |
|---|---|
| Title of the Programme | Research |
| Title of the Project | Fast and sensitive bioanalysis using micromachined electrospray interfaces with μ-scale separations |
| Project Website | ubiosep.com |
| Number of the Project | TO01000232 |
| Project Promoter | Ústav analytické chemie AV ČR,v. v. i. |
| Project Partner from Donor State | SINTEF AS |
| Czech Partner | WATREX Praha, s.r.o. |
| Status | Estimated project duration: 10 / 2020 - 4 / 2024 |
| Total Eligible Costs | 1 294 955 EUR |
| Grant | 1 183 069 EUR |
Project description:
Main goals are:
- Development of micromachined ionization interfaces allowing highly sensitive mass spectrometry analysis of pre-separated biochemical compounds.
- Development of micromachined separation system utilizing the own patented principle of recycling chromatography in which the sample passes repeatedly though the (micro)separation column leading to a significant increase of resolution of its components.
- Development of methodology for coupling of conventional microcolumn-based separation and on-a-chip separation techniques to mass spectrometer through the micromachined interfaces.
- Demonstration of innovation potential of the developed technologies by showcasing two demonstrators targeting high impact applications relevant for life sciences and pharma industries.