Phosphine Ligands for Environmentally Friendly C-C Bond Forming Reactions

Dept 58 - International Relations Department
Dept 58 - International Relations Department


RegionNational coverage
Title of the ProgrammeCZ09 - Czech-Norwegian Research Programme
Title of the ProjectPhosphine Ligands for Environmentally Friendly C-C Bond Forming Reactions
Project Website

Number of the Project7F14392
Project Promoter

Charles University in Prague

Name of Norwegian Partner(s)

University of Bergen

Objective of the Project

This project is aimed at the in silico design, preparation and catalytic evaluation of new highly-active, water-soluble phosphine ligands suitable for applications in practically relevant palladium-catalyzed C–C bond forming reactions and green reaction solvents including pure water. Such ligands should make the mentioned reactions – that are already used in the synthesis of fine chemicals and pharmaceutically active substances at industry scale – less environmentally demanding through increased catalytic activity, minimized production of waste and, mainly, avoidance of hazardous organic solvents and purification steps. The key concept envisaged for the ligand design lies in structural modification of the established privileged ligand types (phosphinobiaryls and phosphinoferrocenes) at their periphery (i.e., far from the active site) with a polar amidosulfonate pendants that will render the new donors water soluble. The ligand synthesis (mostly through the conventional structure variation) and catalytic testing will be supplemented by structural, coordination, electrochemical and theoretical studies that provide a basis for the rationalization of the catalytic properties. All this information will be used in the design of improved by means of artificial evolution.

Approved grant

11 460 000 CZK

Project DurationStart date: 13th July 2015, End date: 20th April 2017