Comparative study of Huntington’s disease using biochemical, immunocytochemical and molecular genetic methods on the mouse, minipig and human tissues and cells

Dept 58 - International Relations Department
Dept 58 - International Relations Department

Published

Updated 23-12-2014
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Project
RegionNational coverage
Title of the ProgrammeCzech-Norwegian Research Programme
Title of the ProjectComparative study of Huntington’s disease using biochemical, immunocytochemical and molecular genetic methods on the mouse, minipig and human tissues and cells
Number of the Project7F14308
Project Promoter

Institute of Animal Physiology and Genetics AS CR

www.iapg.cas.cz

 

Name of Norwegian Partner(s)

Oslo University Hospital

Name of Local Partner(s)

Charles University in Prague

Objective of the Project

Huntington’s disease (HD) is a fatal progressive neurodegenerative disorder caused by a polymorphic trinucleotide CAG repeat expansion in exon 1 of huntingtin gene (HTT). The pathogenesis of this disease, an exact mechanism, how mutant HTT induces selective eurodegeneration, still remains to be elucidated. The grant proposal is based on omparative studies of tissues and cells isolated from mice (R6/2) and minipigs transgenic for N-terminal part of human mutated HTT (TgHD) as well as HD patients. The unique biological material will be examined for CAG instability, mitochondrial functions and Golgi complex proteins, and mutant HTT ggregation process in cooperation of four aboratories (2 Norwegian and 2 Czech).

Approved grant

936 566 EUR

Project DurationStart date: 15th July 2014, End date: 30th April 2017