3D yeast colony genomics: A model for cancer progression and development of drug resistance in biofilms

Dept 58 - International Relations Department
Dept 58 - International Relations Department

Published

Updated 23-12-2014
  • region changed

Project
RegionNational coverage
Title of the ProgrammeCzech-Norwegian Research Programme
Title of the Project3D yeast colony genomics: A model for cancer progression and development of drug resistance in biofilms
Number of the Project7F14083
Project Promoter

Charles University in Prague

www.cuni.cz

 

Name of Norwegian Partner(s)

Oslo University Hospital

Name of Local Partner(s)

Institute of Microbiology of the AS CR

Objective of the Project

Recent findings of both Czech teams behind this project showed that yeast colonies can serve as a unique model system, where colonies behave as simple multicellular organisms formed by differentiated cells with specific properties. Intriguingly, one of the major colonial cell subpopulations gains metabolic properties similar to tumor cells. Natural yeast strains form another type of colonies that resembles fungal biofilms with specific properties which contribute to the high environmental resistance of the entire colony population. With the application of next-generation sequencing methodology provided by the Norwegian team to this model, project YEASTSEQ will contribute to uncovering of molecular mechanisms regulating colony differentiation and the knowledge gleaned will find applications in medicine.

Approved grant

958 038 EUR

Project DurationStart date: 15th October 2014 , End date: 30th April 2017